O 38.six in group two (p = 0.64). Median APACHE II scores were being v…

O 38.six in group 2 (p = 0.sixty four). Median APACHE II scores have been very similar and duration of cardiovascular assist wasn't drastically different concerning the 2 teams. Size of ICU continue to be (median [interquartile PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/21046519 range]) was more time in team two at 6 times [3-12] in comparison to 3 [1-7] (p < 0.001) however this significance was lost when non-survivors were excluded. There was a significantly lower requirement for RRT amongst ICU survivors in group 2 at 15.7 compared to 34 (p = 0.0078). Conclusions: We have shown a significant improvement in rate of RRT associated with implementation of our sepsis resuscitation bundle. Whilst implementation of care bundles has been associated with improved patient outcome, the basis of this relationship remains unclear [2]. Our work fails to demonstrate a significant reduction in mortality however we acknowledge the limitations of a small sample size. Median bundle compliance is higher than in other published work [2] however ongoing quality improvement work may increase this further. We identified a longer length of stay in group 2. This may represent either a longer period of treatment before deciding to change the focus of care to palliation or a faster decline in patients within group 1.References 1. Dellinger et al.: Crit Care Med 2004; 32: 858-73 2. Levy et al.: Intensive Care Med 2010; 36: 222-P048 Dose of norepinephrine in the first 24 hours as a parameter evaluating the effectiveness of treatment in patients with severe sepsis and septic shock P. Szturz 1, P. Folwarzcny1, J. Svancara2, R. Kula1, P. Sevcik1 1 University Hospital and Faculty of Medicine Ostrava University, Ostrava, Czech Republic; 2Institute of Biostatistics and analyses, Masaryk University, Brno, Czech Republic Critical Care 2016, 20(Suppl 2):P048 Introduction: Vasopressor therapy is required to sustain life and maintain perfusion in the face of life-threatening hypotension occurring with severe sepsis and septic shock, even when hypovolemia has not yet been resolved. [1] We hypothesized that a dose of norepinephrine administered in the first 24 hours correlates with the outcome of treatment in patients with PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/18111632 serious sepsis and septic shock. Strategies: We analysed a total of 632 consecutive people with septic shock (sepsis-induced hypotension persisting regardless of satisfactory fluid resuscitation) from your EPOSS databases (Data-based Analysis and Prediction of Consequence in Serious Sepsis), which was formulated to observe and evaluate the procedure efficacy in people with intense sepsis and septic shock. People have been admitted to participating intense care models (twelve hospitals ?seventeen high-volume treatment models) inside the Czech Republic from 1st of January 2011 to fifth of November 2013. The individuals ended up divided into two teams: survivors (n = 316) and nonsurvivors (n = 316). Benefits: The teams of survivors vs. nonsurvivors have been very similar in: age sixty six.0 (39.0; 84.0) vs. sixty eight.0 (34.0;86.0) p = 0.162, gentlemen 184 (fifty eight.2 ) vs. one hundred ninety (sixty.1 ) p = 0.343, APACHE II rating 26.0 (fourteen.0; 39.0) vs. 28.0 (14.0; forty.0) p = 0.565 as well as Letrozole Sofa score ten.0 (four.0 ?sixteen.0) vs. 10.0 (three.0 ?16.0) p = 0.912. Administration with the dose of 30 mL/kg of crystalloids for hypotension or lactate 4 mmol/L (three several hours) and software of vasopressors (six hrs) was carried out in both of those groups, without having statistically significant discrepancies. Statistically significant distinctions amongst survivors vs. nonsurvivors have been discovered within the parameter "Dose of norepinephrine while in the initially 24 hours", 0.211 (0.022 - 1.104).